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Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside

Received: 9 May 2023     Accepted: 26 May 2023     Published: 29 May 2023
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Abstract

Skin acts as a barrier and is an important part of body immune system. External physical, biochemical and other stimuli might cause skin inflammation. Drugs and cosmetics have been developed for skin inflammation treatment. At present, the tests of skin inflammation are mainly conducted on animal and 2D cell models. The former might bring problems such as ethics and authenticity, while the latter cannot fully represent the complex micro-environment of the human body. Microfluidic based Organ-on- a- chips technology provides a new method for drug and cosmetic ingredient screening. Skin-on-a-chip (SOC) has been designed for constructing in vitro skin models. In this paper, a SOC was developed to culture skin-like models in vitro. We tested the differentiation of SOC cultured skin model, and the results showed that its stratum corneum was well differentiated. It indicates that the skin tissue cultured by the SOC bears some similarities to human skin, which can be used for subsequent drug testing. We tested the anti-inflammatory effect of gentiopicroside and compared with dexamethasone. The results showed that 5μg/ml~50μg/ml of gentiopicroside had similar anti-inflammatory effect to 1μM of dexamethasone.

Published in American Journal of Bioscience and Bioengineering (Volume 11, Issue 1)
DOI 10.11648/j.bio.20231101.12
Page(s) 7-13
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Skin, Microfluidic Technology, Anti-inflammatory

References
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Cite This Article
  • APA Style

    Zijia Liu, Yidong Tu, Tianbi Duan, Zhi Lv, Ruixue Yin, et al. (2023). Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside. American Journal of Bioscience and Bioengineering, 11(1), 7-13. https://doi.org/10.11648/j.bio.20231101.12

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    ACS Style

    Zijia Liu; Yidong Tu; Tianbi Duan; Zhi Lv; Ruixue Yin, et al. Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside. Am. J. BioSci. Bioeng. 2023, 11(1), 7-13. doi: 10.11648/j.bio.20231101.12

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    AMA Style

    Zijia Liu, Yidong Tu, Tianbi Duan, Zhi Lv, Ruixue Yin, et al. Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside. Am J BioSci Bioeng. 2023;11(1):7-13. doi: 10.11648/j.bio.20231101.12

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  • @article{10.11648/j.bio.20231101.12,
      author = {Zijia Liu and Yidong Tu and Tianbi Duan and Zhi Lv and Ruixue Yin and Hongbo Zhang},
      title = {Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside},
      journal = {American Journal of Bioscience and Bioengineering},
      volume = {11},
      number = {1},
      pages = {7-13},
      doi = {10.11648/j.bio.20231101.12},
      url = {https://doi.org/10.11648/j.bio.20231101.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20231101.12},
      abstract = {Skin acts as a barrier and is an important part of body immune system. External physical, biochemical and other stimuli might cause skin inflammation. Drugs and cosmetics have been developed for skin inflammation treatment. At present, the tests of skin inflammation are mainly conducted on animal and 2D cell models. The former might bring problems such as ethics and authenticity, while the latter cannot fully represent the complex micro-environment of the human body. Microfluidic based Organ-on- a- chips technology provides a new method for drug and cosmetic ingredient screening. Skin-on-a-chip (SOC) has been designed for constructing in vitro skin models. In this paper, a SOC was developed to culture skin-like models in vitro. We tested the differentiation of SOC cultured skin model, and the results showed that its stratum corneum was well differentiated. It indicates that the skin tissue cultured by the SOC bears some similarities to human skin, which can be used for subsequent drug testing. We tested the anti-inflammatory effect of gentiopicroside and compared with dexamethasone. The results showed that 5μg/ml~50μg/ml of gentiopicroside had similar anti-inflammatory effect to 1μM of dexamethasone.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside
    AU  - Zijia Liu
    AU  - Yidong Tu
    AU  - Tianbi Duan
    AU  - Zhi Lv
    AU  - Ruixue Yin
    AU  - Hongbo Zhang
    Y1  - 2023/05/29
    PY  - 2023
    N1  - https://doi.org/10.11648/j.bio.20231101.12
    DO  - 10.11648/j.bio.20231101.12
    T2  - American Journal of Bioscience and Bioengineering
    JF  - American Journal of Bioscience and Bioengineering
    JO  - American Journal of Bioscience and Bioengineering
    SP  - 7
    EP  - 13
    PB  - Science Publishing Group
    SN  - 2328-5893
    UR  - https://doi.org/10.11648/j.bio.20231101.12
    AB  - Skin acts as a barrier and is an important part of body immune system. External physical, biochemical and other stimuli might cause skin inflammation. Drugs and cosmetics have been developed for skin inflammation treatment. At present, the tests of skin inflammation are mainly conducted on animal and 2D cell models. The former might bring problems such as ethics and authenticity, while the latter cannot fully represent the complex micro-environment of the human body. Microfluidic based Organ-on- a- chips technology provides a new method for drug and cosmetic ingredient screening. Skin-on-a-chip (SOC) has been designed for constructing in vitro skin models. In this paper, a SOC was developed to culture skin-like models in vitro. We tested the differentiation of SOC cultured skin model, and the results showed that its stratum corneum was well differentiated. It indicates that the skin tissue cultured by the SOC bears some similarities to human skin, which can be used for subsequent drug testing. We tested the anti-inflammatory effect of gentiopicroside and compared with dexamethasone. The results showed that 5μg/ml~50μg/ml of gentiopicroside had similar anti-inflammatory effect to 1μM of dexamethasone.
    VL  - 11
    IS  - 1
    ER  - 

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Author Information
  • School of Mechanics, East China University of Science and Technology, Shanghai, China

  • Shanghai Inoherb Ltd., Shanghai, China

  • Shanghai Inoherb Ltd., Shanghai, China

  • Shanghai Inoherb Ltd., Shanghai, China

  • School of Mechanics, East China University of Science and Technology, Shanghai, China

  • School of Mechanics, East China University of Science and Technology, Shanghai, China

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